The importance of plasma protein binding (PPB) in modulating the effective drug
concentration at pharmacological target sites has been the topic of significant discussion …

With the increasing use of mycophenolic acid (MPA) in solid organ transplantation, the need
for more accurate drug dosing has become evident. Personalized immunosuppressive …

WITHDRAWN: Executive Summary - The International Society for Heart and Lung
Transplantation (ISHLT) guidelines for the care of heart transplant recipients - ScienceDirect Skip …

CHAIR: Costanzo MR: Midwest Heart Foundation, Lombard Illinois, USA TASK FORCE 1:
Dipchand A: Hospital for Sick Children, Toronto Ontario, Canada; Starling R: Cleveland …

This review aims to provide an update of the literature on the pharmacology and toxicology
of mycophenolate in solid organ transplant recipients. Mycophenolate is now the …

Background. We hypothesized that a high within-patient variability in clearance of tacrolimus
and mycophenolate mofetil (MMF) would put patients at risk for periods of over-or …

The innate and adaptive immune systems work as a complex interplay between different cell
types, involving cytokines and chemokines mediating extracellular and paracrine effects. At …

Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and
in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that …

Monitoring immunosuppressive drugs (ISDs) in blood or plasma is still a key therapeutic
drug monitoring (TDM) application in clinical settings. Narrow target ranges and severe side …

Aims Tacrolimus and mycophenolic acid dosing after renal transplantation is individualized
through therapeutic drug monitoring (TDM). Home‐based dried blood spot (DBS) sampling …