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Understanding PTEN regulation: PIP2, polarity and protein stability
The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits
phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating …
phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating …
[HTML][HTML] Directional sensing during chemotaxis
Cells have the innate ability to sense and move towards a variety of chemoattractants. We
investigate the pathways by which cells sense and respond to chemoattractant gradients …
investigate the pathways by which cells sense and respond to chemoattractant gradients …
Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression
Second messengers control a wide range of important cellular functions in eukaryotes and
prokaryotes. Here we show that cyclic di-GMP, a global bacterial second messenger …
prokaryotes. Here we show that cyclic di-GMP, a global bacterial second messenger …
How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility
To regulate shape changes, motility and chemotaxis in eukaryotic cells, signal transduction
pathways channel extracellular stimuli to the reorganization of the actin cytoskeleton. The …
pathways channel extracellular stimuli to the reorganization of the actin cytoskeleton. The …
Eukaryotic chemotaxis at a glance
A Bagorda, CA Parent - Journal of cell science, 2008 - journals.biologists.com
Chemotaxis is a fundamental process in which cells migrate directionally when they are
exposed to external chemical gradients. It is exhibited by a wide variety of cell types and …
exposed to external chemical gradients. It is exhibited by a wide variety of cell types and …
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
Actin-based protrusions are reinforced through positive feedback, but it is unclear what
restricts their size, or limits positive signals when they retract or split. We identify an …
restricts their size, or limits positive signals when they retract or split. We identify an …
Steering yourself by the bootstraps: how cells create their own gradients for chemotaxis
Chemotaxis, where cell movement is steered by chemical gradients, is a widespread and
essential way of organising cell behaviour. But where do the instructions come from–who …
essential way of organising cell behaviour. But where do the instructions come from–who …
Self-generated gradients yield exceptionally robust steering cues
Chemotaxis is a widespread mechanism that allows migrating cells to steer to where they
are needed. Attractant gradients may be imposed by external sources, or self-generated …
are needed. Attractant gradients may be imposed by external sources, or self-generated …
Self-cleaving peptides for expression of multiple genes in Dictyostelium discoideum
The social amoeba Dictyostelium discoideum is a model for a wide range of biological
processes including chemotaxis, cell-cell communication, phagocytosis, and development …
processes including chemotaxis, cell-cell communication, phagocytosis, and development …
LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
O Susanto, YWH Koh, N Morrice… - Journal of cell …, 2017 - journals.biologists.com
Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA)
gradients. The cells break down LPA, which is present at high levels around the tumours …
gradients. The cells break down LPA, which is present at high levels around the tumours …