Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Towards a biologically annotated brain connectome
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …
Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies
Isolated rapid eye movement sleep behaviour disorder (iRBD) is a sleep disorder
characterized by the loss of rapid eye movement sleep muscle atonia and the appearance of …
characterized by the loss of rapid eye movement sleep muscle atonia and the appearance of …
[HTML][HTML] Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease
Parkinson's disease pathology is hypothesized to spread through the brain via axonal
connections between regions and is further modulated by local vulnerabilities within those …
connections between regions and is further modulated by local vulnerabilities within those …
Fixel‐Based Analysis Reveals Whole‐Brain White Matter Abnormalities in Cervical Dystonia
Background Cervical dystonia (CD) is a form of isolated focal dystonia typically associated to
abnormal head, neck, and shoulder movements and postures. The complexity of the clinical …
abnormal head, neck, and shoulder movements and postures. The complexity of the clinical …
Changes in Action Tremor in Parkinson's Disease over Time: Clinical and Neuroimaging Correlates
Background The various symptoms of Parkinson's disease (PD) may change differently over
time as the disease progresses. Tremor usually manifests early in the disease, but unlike …
time as the disease progresses. Tremor usually manifests early in the disease, but unlike …
Identification of Parkinson's disease subtypes with distinct brain atrophy progression and its association with clinical progression
Background Parkinson's disease (PD) patients suffer from progressive gray matter volume
(GMV) loss, but whether distinct patterns of atrophy progression exist within PD are still …
(GMV) loss, but whether distinct patterns of atrophy progression exist within PD are still …
Connectome-based biophysical models of pathological protein spreading in neurodegenerative diseases
Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration or death of neurons. The complexity of clinical symptoms and irreversibility of …
degeneration or death of neurons. The complexity of clinical symptoms and irreversibility of …
Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder
Background Synucleinopathies manifest as a spectrum of disorders that vary in features and
severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) and dementia …
severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) and dementia …
Network spreading and local biological vulnerability in amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that
predominantly targets the motor system. Spread of pathology is thought to be driven by both …
predominantly targets the motor system. Spread of pathology is thought to be driven by both …