HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
Generalists and specialists: a new view of how MHC class I molecules fight infectious pathogens
J Kaufman - Trends in Immunology, 2018 - cell.com
In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the
chicken MHC is simple and compact with a single dominantly expressed class I molecule …
chicken MHC is simple and compact with a single dominantly expressed class I molecule …
Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation
Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide
loading complex plays a critical role in antigen presentation and immune recognition …
loading complex plays a critical role in antigen presentation and immune recognition …
HLA tapasin independence: broader peptide repertoire and HIV control
AA Bashirova, M Viard, V Naranbhai… - Proceedings of the …, 2020 - National Acad Sciences
Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in
the absence of tapasin, an essential component of the peptide loading complex. We …
the absence of tapasin, an essential component of the peptide loading complex. We …
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
Immunological chaperones tapasin and TAP binding protein, related (TAPBPR) play key
roles in antigenic peptide optimization and quality control of nascent class I major …
roles in antigenic peptide optimization and quality control of nascent class I major …
Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation
ET Abualrous, J Sticht, C Freund - Current Opinion in Immunology, 2021 - Elsevier
The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions
in the genomes of vertebrates. In the human population, thousands of MHC gene variants …
in the genomes of vertebrates. In the human population, thousands of MHC gene variants …
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding
PE Chappell, EK Meziane, M Harrison, Ł Magiera… - elife, 2015 - elifesciences.org
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of
adaptive immune responses, playing crucial roles in many kinds of disease and in …
adaptive immune responses, playing crucial roles in many kinds of disease and in …
Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity
IK Müller, C Winter, C Thomas, RM Spaapen… - Nature …, 2022 - nature.com
Adaptive immunity depends on cell surface presentation of antigenic peptides by major
histocompatibility complex class I (MHC I) molecules and on stringent ER quality control in …
histocompatibility complex class I (MHC I) molecules and on stringent ER quality control in …
Factors affecting HLA expression: A review
BS Carey, KV Poulton, A Poles - International journal of …, 2019 - Wiley Online Library
The detection and semiquantitative measurement of circulating human leucocyte antigen
(HLA)‐specific antibodies is essential for the management of patients before and after …
(HLA)‐specific antibodies is essential for the management of patients before and after …
Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: towards a unifying view
JAL de Castro, C Alvarez-Navarro, A Brito, P Guasp… - Molecular …, 2016 - Elsevier
The inflammatory diseases that are most strongly associated with major histocompatibility
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …