The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Quantitative proteomics identifies proteins enriched in large and small extracellular vesicles

A Lischnig, M Bergqvist, T Ochiya… - Molecular & Cellular …, 2022 - mcponline.org
There is a long-held consensus that several proteins are unique to small extracellular
vesicles (EVs), such as exosomes. However, recent studies have shown that several of …

Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

SI Van De Wakker, FM Meijers, JPG Sluijter… - Pharmacological …, 2023 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved
in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic …

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

A Rai, H Fang, B Claridge, RJ Simpson… - Journal of …, 2021 - Wiley Online Library
The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental
signalling gateway by bridging intra‐and extracellular signalling networks, dictates EVs' …

The discovery of extracellular vesicles and their emergence as a next-generation therapy

A Rai, B Claridge, J Lozano, DW Greening - Circulation research, 2024 - ahajournals.org
From their humble discovery as cellular debris to cementing their natural capacity to transfer
functional molecules between cells, the long-winded journey of extracellular vesicles (EVs) …

The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation

S Park, R Dahn, E Kurt, A Presle, K VanDenHeuvel… - Developmental cell, 2023 - cell.com
Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is
released post-abscission inside large extracellular vesicles called MB remnants (MBRs) …

Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

SI van de Wakker, J Bauzá‐Martinez… - Journal of …, 2024 - Wiley Online Library
Cardiac progenitor cell (CPC)‐derived small extracellular vesicles (sEVs) exhibit great
potential to stimulate cardiac repair. However, the multifaceted nature of sEV heterogeneity …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Extracellular vesicles-on the cusp of a new language in the biological sciences

G Raposo, PD Stahl - Extracellular Vesicles and Circulating …, 2023 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) play a key role both in physiological balance and homeostasis
and in disease processes through their ability to participate in intercellular signaling and …