Abstract Hydantoin, imidazolidine-2, 4-dione, is a non-aromatic five-membered heterocycle,
which is considered a valuable, privileged scaffold in medicinal chemistry. The importance …

Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …

Hydantoin compounds are important heterocyclic scaffolds and a class of well-known
bioactive molecules with a broad spectrum of pharmacological properties. Consequently …

Heterocyclic benzimidazole derivatives 3a–h, 5a–c and 7a–d have been synthesized by
condensation of succinic acid (1) homophthalic acid (4) and 2, 3-pyrazinedicarboxlic acid (6) …

The reactivity of amidines makes them valuable as building blocks for the synthesis of
heterocyclic motifs of biological relevance, for functional materials, for organo-catalysts and …

Lewis base-catalyzed cascade nucleophilic/aza-Michael addition reaction of N-alkoxy β-oxo-
acrylamides with isocyanates has been developed to afford various highly functionalized …

Maleimide and amidine functionalities often appear in medicinal and natural product targets.
We describe a catalyst-free, three-component coupling reaction for the synthesis of …

Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …

Thiazolyl pyrazoles and isoxazoles were prepared and their antimicrobial activity studied.
Chloro-and nitro-substituted thiazolyl isoxazoles were potential antibacterial agents against …

This study aims to design and synthesize a number of novel pyran, thiophene, and pyridine
derivatives incorporating thiazole ring and evaluate their antitumor inhibition (μM) as …