Human organoids: New strategies and methods for analyzing human development and disease
NS Corsini, JA Knoblich - Cell, 2022 - cell.com
For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …
obtained primarily by experiments in animal models. While this has allowed researchers to …
Unraveling mechanisms of human brain evolution
MA Lancaster - Cell, 2024 - cell.com
Evolutionary changes in human brain structure and function have enabled our specialized
cognitive abilities. How these changes have come about genetically and functionally has …
cognitive abilities. How these changes have come about genetically and functionally has …
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …
multiple organ systems including the central nervous system (CNS). Yet, there is no …
Generating human neural diversity with a multiplexed morphogen screen in organoids
Morphogens choreograph the generation of remarkable cellular diversity in the develo**
nervous system. Differentiation of stem cells in vitro often relies upon the combinatorial …
nervous system. Differentiation of stem cells in vitro often relies upon the combinatorial …
Choroid plexus mast cells drive tumor-associated hydrocephalus
Y Li, C Di, S Song, Y Zhang, Y Lu, J Liao, B Lei… - Cell, 2023 - cell.com
Tumor-associated hydrocephalus (TAH) is a common and lethal complication of brain
metastases. Although other factors beyond mechanical obstructions have been suggested …
metastases. Although other factors beyond mechanical obstructions have been suggested …
[HTML][HTML] A review of protocols for brain organoids and applications for disease modeling
CN Mayhew, R Singhania - STAR protocols, 2023 - Elsevier
Recent breakthroughs in human stem cell technologies have enabled the generation of 3D
brain organoid platforms for modeling human neurodevelopment and disease. Here, we …
brain organoid platforms for modeling human neurodevelopment and disease. Here, we …
Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway
Abnormalities in thalamocortical crosstalk can lead to neuropsychiatric disorders. Variants in
CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium …
CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium …
High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids
Current protocols for producing cerebellar neurons from human pluripotent stem cells
(hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their …
(hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their …
Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid maturation and does not impede growth
Although biochemical regulation has been extensively studied in organoid modeling
protocols, the role of mechanoregulation in directing stem cell fate and organoid …
protocols, the role of mechanoregulation in directing stem cell fate and organoid …
Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip
Microphysiological systems (MPS) designed to study the complexities of the peripheral and
central nervous systems have made marked improvements over the years and have allowed …
central nervous systems have made marked improvements over the years and have allowed …