Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic
cancer treatments by facilitating targeted delivery to a desired site. The physical and …

Introduction Gene delivery technologies are being developed for an increasing number of
biomedical applications, with delivery vehicles including viruses and non-viral materials …

Nanoparticle (NP)-based mRNA cancer vaccines hold great promise to realize personalized
cancer treatments. To advance this technology requires delivery formulations for efficient …

The ongoing outbreak of the novel coronavirus disease 2019 (COVID-19) originating from
Wuhan, China, draws worldwide concerns due to its long incubation period and strong …

Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …

Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …

Nonviral gene therapy holds great promise but has not delivered treatments for clinical
application to date. Lack of safe and efficient gene delivery vectors is the major hurdle …

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses
for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work …

Current therapies for most neurodegenerative disorders are only symptomatic in nature and
do not change the course of the disease. Gene therapy plays an important role in disease …

This review provides an overview of smart chemistry developed and utilized in the last 5–10
years in polymer-based drug delivery nanomedicine. Smart chemistry not only facilitates the …