[HTML][HTML] Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment

V Rajeev, DY Fann, QN Dinh, HA Kim, TM De Silva… - Theranostics, 2022 - ncbi.nlm.nih.gov
The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

Social isolation and cognitive function in later life: a systematic review and meta-analysis

IEM Evans, A Martyr, R Collins… - Journal of Alzheimer's …, 2019 - content.iospress.com
Background: There is some evidence to suggest that social isolation may be associated with
poor cognitive function in later life. However, findings are inconsistent and there is wide …

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

E Nichols, JD Steinmetz, SE Vollset… - The Lancet Public …, 2022 - thelancet.com
Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …

2018 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2018 - Elsevier
This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on …

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

E Nichols, CEI Szoeke, SE Vollset, N Abbasi… - The Lancet …, 2019 - thelancet.com
Background The number of individuals living with dementia is increasing, negatively
affecting families, communities, and health-care systems around the world. A successful …

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

SL James, A Theadom, RG Ellenbogen… - The Lancet …, 2019 - thelancet.com
Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly
recognised as global health priorities in view of the preventability of most injuries and the …

Anticholinergic drug exposure and the risk of dementia: a nested case-control study

CAC Coupland, T Hill, T Dening, R Morriss… - JAMA internal …, 2019 - jamanetwork.com
Importance Anticholinergic medicines have short-term cognitive adverse effects, but it is
uncertain whether long-term use of these drugs is associated with an increased risk of …

2016 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2016 - Elsevier
This report describes the public health impact of Alzheimer's disease, including incidence
and prevalence, mortality rates, costs of care, and the overall impact on caregivers and …

[HTML][HTML] Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective

M Baumgart, HM Snyder, MC Carrillo, S Fazio… - Alzheimer's & …, 2015 - Elsevier
An estimated 47 million people worldwide are living with dementia in 2015, and this number
is projected to triple by 2050. In the absence of a disease-modifying treatment or cure …

Vascular cognitive impairment

M Dichgans, D Leys - Circulation research, 2017 - Am Heart Assoc
Cerebrovascular disease typically manifests with stroke, cognitive impairment, or both.
Vascular cognitive impairment refers to all forms of cognitive disorder associated with …