Challenges of applying multicellular tumor spheroids in preclinical phase

SJ Han, S Kwon, KS Kim - Cancer cell international, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs

MAG Barbosa, CPR Xavier, RF Pereira, V Petrikaitė… - Cancers, 2021 - mdpi.com
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

SY Qin, JQ Feng, YJ Cheng, WL Liu, AQ Zhang… - Coordination Chemistry …, 2024 - Elsevier
In the last few decades, we have witnessed the great advances of molecular self-assembly
in biomedical applications. Among the building blocks for molecular self-assembly, peptide …

Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling

KH Griffin, SW Fok, J Kent Leach - NPJ Regenerative Medicine, 2022 - nature.com
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

Design of spherically structured 3D in vitro tumor models-Advances and prospects

LP Ferreira, VM Gaspar, JF Mano - Acta biomaterialia, 2018 - Elsevier
Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …

MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity

A Peirsman, E Blondeel, T Ahmed, J Anckaert… - Nature …, 2021 - nature.com
Spheroids are three-dimensional cellular models with widespread basic and translational
application across academia and industry. However, methodological transparency and …

Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening

JM Lee, DY Park, L Yang, EJ Kim, CD Ahrberg… - Scientific reports, 2018 - nature.com
Even though in vitro co-culture tumor spheroid model plays an important role in screening
drug candidates, its wide applications are currently limited due to the lack of reliable and …

Targeting mitochondria for treatment of chemoresistant ovarian cancer

E Emmings, S Mullany, Z Chang, CN Landen Jr… - International journal of …, 2019 - mdpi.com
Ovarian cancer is the leading cause of death from gynecologic malignancy in the Western
world. This is due, in part, to the fact that despite standard treatment of surgery and …

Control of thiol-maleimide reaction kinetics in PEG hydrogel networks

LE Jansen, LJ Negrón-Piñeiro, S Galarza, SR Peyton - Acta biomaterialia, 2018 - Elsevier
Michael-type addition reactions are widely used to polymerize biocompatible hydrogels. The
thiol-maleimide modality achieves the highest macromer coupling efficiency of the reported …

Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models

MN Brodeur, K Simeone, K Leclerc-Deslauniers… - Scientific reports, 2021 - nature.com
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key
challenges in develo** effective therapeutics is the poor translation of preclinical models …