HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19
Background Understanding how HLA polymorphisms may affect both susceptibility, course
and severity of Covid-19 infection could help both at the clinical level to identify individuals …
and severity of Covid-19 infection could help both at the clinical level to identify individuals …
Natural selection and infectious disease in human populations
EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …
genetic variation in modern populations, and this has important implications for the growing …
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
L Swadling, S Capone, RD Antrobus, A Brown… - Science translational …, 2014 - science.org
A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV
infects millions of people worldwide and is a leading cause of liver cirrhosis and …
infects millions of people worldwide and is a leading cause of liver cirrhosis and …
[HTML][HTML] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis
Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …
genetic control of the human immune system during homeostasis is poorly understood. We …
[HTML][HTML] Epidemiology and natural history of hepatitis C virus infection
Hepatitis C virus (HCV) affects 130-210 million people worldwide and is one of the major
risk factors for hepatocellular carcinoma. Globally, at least one third of hepatocellular …
risk factors for hepatocellular carcinoma. Globally, at least one third of hepatocellular …
[PDF][PDF] Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses
WO Osburn, AE Snider, BL Wells, R Latanich… - …, 2014 - Wiley Online Library
The contribution of humoral immune responses to spontaneous control of hepatitis C virus
(HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses …
(HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses …