Macroscopic gradients of synaptic excitation and inhibition in the neocortex

XJ Wang - Nature reviews neuroscience, 2020 - nature.com
With advances in connectomics, transcriptome and neurophysiological technologies, the
neuroscience of brain-wide neural circuits is poised to take off. A major challenge is to …

Reconceptualizing functional brain connectivity in autism from a developmental perspective

LQ Uddin, K Supekar, V Menon - Frontiers in human neuroscience, 2013 - frontiersin.org
While there is almost universal agreement amongst researchers that autism is associated
with alterations in brain connectivity, the precise nature of these alterations continues to be …

Sliced human cortical organoids for modeling distinct cortical layer formation

X Qian, Y Su, CD Adam, AU Deutschmann, SR Pather… - Cell stem cell, 2020 - cell.com
Human brain organoids provide unique platforms for modeling development and diseases
by recapitulating the architecture of the embryonic brain. However, current organoid …

EEG analytics for early detection of autism spectrum disorder: a data-driven approach

WJ Bosl, H Tager-Flusberg, CA Nelson - Scientific reports, 2018 - nature.com
Autism spectrum disorder (ASD) is a complex and heterogeneous disorder, diagnosed on
the basis of behavioral symptoms during the second year of life or later. Finding scalable …

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

X Wang, AL Bey, BM Katz, A Badea, N Kim… - Nature …, 2016 - nature.com
Human neuroimaging studies suggest that aberrant neural connectivity underlies
behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural …

Salience network–based classification and prediction of symptom severity in children with autism

LQ Uddin, K Supekar, CJ Lynch, A Khouzam… - JAMA …, 2013 - jamanetwork.com
Importance Autism spectrum disorder (ASD) affects 1 in 88 children and is characterized by
a complex phenotype, including social, communicative, and sensorimotor deficits. Autism …

Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat

W Zhao, KG Johnston, H Ren, X Xu, Q Nie - Nature Communications, 2023 - nature.com
Neural communication networks form the fundamental basis for brain function. These
communication networks are enabled by emitted ligands such as neurotransmitters, which …

The implications of brain connectivity in the neuropsychology of autism

JO Maximo, EJ Cadena, RK Kana - Neuropsychology review, 2014 - Springer
Autism is a neurodevelopmental disorder that has been associated with atypical brain
functioning. Functional connectivity MRI (fcMRI) studies examining neural networks in …

[HTML][HTML] Developmental changes in large-scale network connectivity in autism

JS Nomi, LQ Uddin - NeuroImage: Clinical, 2015 - Elsevier
Background Disrupted cortical connectivity is thought to underlie the complex cognitive and
behavior profile observed in individuals with autism spectrum disorder (ASD). Previous …

[HTML][HTML] Investigating white matter development in infancy and early childhood using myelin water faction and relaxation time map**

SCL Deoni, DC Dean III, J O'Muircheartaigh, H Dirks… - Neuroimage, 2012 - Elsevier
The elaboration of the myelinated white matter is essential for normal neurodevelopment,
establishing and mediating rapid communication pathways throughout the brain. These …