Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …

The discovery of tumor-initiating cells endowed with stem-like features has added a further
level of complexity to the pathobiology of neoplastic diseases. In the attempt of dissecting …

Purpose To compile a list of genes that have been reported to be affected by external
ionizing radiation (IR) and to assess their performance as candidate biomarkers for …

People exposed to ionizing radiation (IR) both for diagnostic and therapeutic purposes is
constantly increasing. Since the use of IR involves a risk of harmful effects, such as the DNA …

The possibility of a large-scale acute radiation exposure necessitates the development of
new methods that could provide rapid individual dose estimates with high sample …

The visualisation of DNA damage response proteins enables the indirect measurement of
DNA damage. Soon after the occurrence of a DNA double-strand break (DSB), the formation …

The cytokinesis-block micronucleus (CBMN) assay has become a fully-validated and
standardized method for radiation biodosimetry. The assay is typically performed using …

The use of micronucleus (MN) assays in in vitro genetic toxicology testing, radiation
biodosimetry and population biomonitoring to study the genotoxic impacts of environment …

Abstract Analysis of phosphorylated histone protein H2AX (γH2AX) foci is currently the most
sensitive method to detect DNA double‐strand breaks (DSB). This protein modification has …

We demonstrate the use of high-throughput biodosimetry platforms based on commercial
high-throughput/high-content screening robotic systems. The cytokinesis-block …