Potential second-hits in hereditary hemorrhagic telangiectasia

C Bernabeu, P Bayrak-Toydemir, J McDonald… - Journal of Clinical …, 2020 - mdpi.com
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder
that presents with telangiectases in skin and mucosae, and arteriovenous malformations …

Recent advances in basic research for brain arteriovenous malformation

L Barbosa Do Prado, C Han, SP Oh, H Su - International journal of …, 2019 - mdpi.com
Arteriovenous malformations (AVMs) are abnormal connections of vessels that shunt blood
directly from arteries into veins. Rupture of brain AVMs (bAVMs) can cause life-threatening …

Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression

PA Guerrero, JH Tchaicha, Z Chen, JE Morales… - Oncogene, 2017 - nature.com
Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer
cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche …

Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation

P Cheng, LI Ma, S Shaligram, EJ Walker… - Journal of …, 2019 - thejns.org
OBJECTIVE A high level of vascular endothelial growth factor (VEGF) has been implicated
in brain arteriovenous malformation (bAVM) bleeding and rupture. However, direct evidence …

Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease

Y Cao, H Su, J Zeng, Y **e, Z Liu, F Liu, Y Qiu, F Yi… - Translational …, 2024 - Elsevier
Diabetic kidney disease (DKD) is one of the leading causes to develop end-stage kidney
disease worldwide. Pericytes are implicated in the development of tissue fibrosis. However …

Dysregulation of microRNA and intracerebral hemorrhage: roles in neuroinflammation

H Kashif, D Shah, S Sukumari-Ramesh - International journal of …, 2021 - mdpi.com
Intracerebral hemorrhage (ICH) is a major public health problem and devastating subtype of
stroke with high morbidity and mortality. Notably, there is no effective treatment for ICH …

Cellular loci involved in the development of brain arteriovenous malformations

Z Shabani, J Schuerger, H Su - Frontiers in Human Neuroscience, 2022 - frontiersin.org
Brain arteriovenous malformations (bAVMs) are abnormal vessels that are prone to rupture,
causing life-threatening intracranial bleeding. The mechanism of bAVM formation is poorly …

[HTML][HTML] miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

YY Bai, JZ Niu - Molecular Medicine Reports, 2020 - spandidos-publications.com
Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity.
MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of …

CpG-ODN exerts a neuroprotective effect via the TLR9/pAMPK signaling pathway by activation of autophagy in a neonatal HIE rat model

L Ye, Z Feng, D Doycheva, J Malaguit, B Dixon… - Experimental …, 2018 - Elsevier
Abstract Hypoxic Ischemic Encephalopathy (HIE) is an injury caused to the brain due to
prolonged lack of oxygen and blood supply which results in death or long-term disabilities …

Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage

Z Feng, L Ye, D Klebe, Y Ding, ZN Guo… - Journal of Cerebral …, 2019 - journals.sagepub.com
CD200 has been reported to be neuroprotective in neurodegenerative diseases. However,
the potential protective effects of CD200 in germinal matrix hemorrhage (GMH) have not …