Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique …

Proteases are ubiquitous in nature, whereas naturally occurring peptide ligases, enzymes
catalyzing the reverse reactions of proteases, are rare occurrences. Here we describe the …

The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as
pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive …

With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Genome mining is a computational method for the automatic detection and annotation of
biosynthetic gene clusters (BGCs) from genomic data. This approach has been increasingly …

Macrocyclic peptides are an emerging class of therapeutics that can modulate protein–
protein interactions. In contrast to the heavily automated high-throughput screening systems …

Natural bioactive peptide discovery is a challenging and time-consuming process. However,
advances in synthetic biology are providing promising new avenues in peptide engineering …

Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …