Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable,
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …

Genetically encoded photosensitizers (PSs), eg ROS generating proteins, correspond to a
novel class of PSs that are highly desirable for biological and medical applications since …

Many cellular processes are driven by spatially and temporally regulated redox-dependent
signaling events. Although mounting evidence indicates that organelles such as the …

The fluorescent protein KillerRed, a new type of biological photosensitizer, is considered as
a promising substitute for current synthetic photosensitizes used in photodynamic therapy …

Background Genetically encoded photosensitizers are a promising optogenetic instrument
for light-induced production of reactive oxygen species in desired locations within cells in …

Reactive oxygen species (ROS)-induced DNA damage is repaired by the base excision
repair pathway. However, the effect of chromatin structure on BER protein recruitment to …

This work was aimed at the complex analysis of the metabolic and oxygen statuses of
tumors in vivo after photodynamic therapy (PDT). Studies were conducted on mouse tumor …

Genetically encoded photosensitizers, proteins that produce reactive oxygen species when
illuminated with visible light, are increasingly used as optogenetic tools. Their applications …

High immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of
the therapeutic agents based on Pseudomonas aeruginosa exotoxin A. In this work, we …

Photodynamic diagnosis (PDD) and therapy (PDT) are emerging, non/minimally invasive
techniques for cancer diagnosis and treatment. Both techniques require a photosensitizer …