The genetic basis of childhood obesity: A systematic review
Overweight and obesity in childhood and adolescence represents one of the most
challenging public health problems of our century owing to its epidemic proportions and the …
challenging public health problems of our century owing to its epidemic proportions and the …
The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity
R Gutierrez, E Fonseca, SA Simon - Cellular and Molecular Life Sciences, 2020 - Springer
Throughout the animal kingdom sucrose is one of the most palatable and preferred tastants.
From an evolutionary perspective, this is not surprising as it is a primary source of energy …
From an evolutionary perspective, this is not surprising as it is a primary source of energy …
Liraglutide restores impaired associative learning in individuals with obesity
Survival under selective pressure is driven by the ability of our brain to use sensory
information to our advantage to control physiological needs. To that end, neural circuits …
information to our advantage to control physiological needs. To that end, neural circuits …
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives
Maintaining healthy body weight is increasingly difficult in our obesogenic environment.
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …
Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits
We present the results of a GWAS of food liking conducted on 161,625 participants from the
UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic …
UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic …
Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and
occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that …
occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that …
Ultra-processed foods and binge eating: A retrospective observational study
Objectives There is increasing evidence of the impact of ultra-processed foods on multiple
metabolic and neurobiological pathways, including those involved in eating behaviors, both …
metabolic and neurobiological pathways, including those involved in eating behaviors, both …
Dietary sugar inhibits satiation by decreasing the central processing of sweet taste
From humans to vinegar flies, exposure to diets rich in sugar and fat lowers taste sensation,
changes food choices, and promotes feeding. However, how these peripheral alterations …
changes food choices, and promotes feeding. However, how these peripheral alterations …
Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction
I Morales - Appetite, 2022 - Elsevier
Obesity and other eating disorders are marked by dysregulations to brain metabolic,
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …
Food memory circuits regulate eating and energy balance
TR Pardo-Garcia, K Gu, RKR Woerner, M Dus - Current Biology, 2023 - cell.com
In mammals, learning circuits play an essential role in energy balance by creating
associations between sensory cues and the rewarding qualities of food. This process is …
associations between sensory cues and the rewarding qualities of food. This process is …