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Molecular pathways of nonalcoholic fatty liver disease development and progression
F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
Drug‐induced liver injury in the context of nonalcoholic fatty liver disease–a physiopathological and clinical integrated view
F Bessone, M Dirchwolf, MA Rodil… - Alimentary …, 2018 - Wiley Online Library
Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …
ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast …
J Hu, Y Zhang, X Jiang, H Zhang, Z Gao, Y Li… - Journal of Experimental …, 2019 - Springer
Background Triple-negative breast cancer (TNBC) is often aggressive and associated with a
poor prognosis. Due to the lack of available targeted therapies and to problems of resistance …
poor prognosis. Due to the lack of available targeted therapies and to problems of resistance …
Astaxanthin attenuates hypertensive vascular remodeling by protecting vascular smooth muscle cells from oxidative stress‐induced mitochondrial dysfunction
Y Chen, S Li, Y Guo, H Yu, Y Bao, X **n… - Oxidative Medicine …, 2020 - Wiley Online Library
Oxidative stress aggravates mitochondrial injuries and accelerates the proliferation of
vascular smooth muscle cells (VSMCs), which are important mechanisms contributing to …
vascular smooth muscle cells (VSMCs), which are important mechanisms contributing to …
Exosomes derived from miR‐214‐enriched bone marrow‐derived mesenchymal stem cells regulate oxidative damage in cardiac stem cells by targeting CaMKII
Y Wang, R Zhao, D Liu, W Deng, G Xu… - Oxidative Medicine …, 2018 - Wiley Online Library
Cardiac stem cells (CSCs) have emerged as one of the most promising stem cells for
cardiac protection. Recently, exosomes from bone marrow‐derived mesenchymal stem cells …
cardiac protection. Recently, exosomes from bone marrow‐derived mesenchymal stem cells …
Heat stress induced apoptosis is triggered by transcription-independent p53, Ca2+ dyshomeostasis and the subsequent Bax mitochondrial translocation
ZT Gu, L Li, F Wu, P Zhao, H Yang, YS Liu, Y Geng… - Scientific reports, 2015 - nature.com
In this study, We demonstrated that Bax mitochondrial translocation plays a vital role in the
initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition …
initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition …
How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?
N Tajeddine - Biochimica et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Background Mitochondrial membrane permeabilisation (MMP) is classically considered as a
point of no return in several forms of cell death and is involved in numerous diseases such …
point of no return in several forms of cell death and is involved in numerous diseases such …
Trifluoperazine mitigates cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in mice by modulating the AKT/mTOR-driven autophagy …
AK Saleh, NA El-Mahdy, TA El-Masry, AH El-Kadem - Life Sciences, 2024 - Elsevier
Aim This study aims to investigate the hepatoprotective effect of the antipsychotic drug
trifluoperazine (TFP) against cyclophosphamide (CPA)-induced hepatic injury by exploring …
trifluoperazine (TFP) against cyclophosphamide (CPA)-induced hepatic injury by exploring …
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization
Tauopathies are a class of neurodegenerative disorders characterized by abnormal
deposition of post-translationally modified tau protein in the human brain. Tauopathies are …
deposition of post-translationally modified tau protein in the human brain. Tauopathies are …
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium
HX Wang, R Zhang, Z Li, LS Wang, Y Yu… - Toxicology …, 2021 - academic.oup.com
Cypermethrin, one kind of pyrethroid pesticides, has been shown to act as endocrine-
disrupting chemicals (EDCs). The purpose of this study was to explore the roles of Sertoli …
disrupting chemicals (EDCs). The purpose of this study was to explore the roles of Sertoli …