Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

Abstract SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19
pandemic and is a major public health concern nowadays. The rapid and global spread of …

Studies have shown that SARS-CoV-2 has the ability to activate and mature proinflammatory
cytokines in the body. Cytokine markers are a group of polypeptide signalling molecules that …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19.
Investigating the underlying mechanisms, we find that while primary human airway epithelia …