Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …

Hydroxylation of aryl carbon–hydrogen bonds with transition metal catalysts has proven
challenging when oxygen is used as the oxidant. Here, we report a palladium complex …

P450BM3 (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been
extensively studied over a period of almost forty years. The enzyme has been redesigned to …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Cytochromes P450 (CYPs) belong to the superfamily of heme b containing
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …

Cytochrome P450 monooxygenases (P450s) are versatile biocatalysts that catalyze the
regio-and stereospecic oxidation of non-activated hydrocarbons under mild conditions …