Background: The existence of cerebral reperfusion injury in human beings remains
controversial. Thus, we aimed to explore the presence of reperfusion injury in acute …

With the larger variety of methods employed, recanalization therapy is increasingly used to
treat acute ischemic stroke resulting in about one-third of patients undergoing early …

Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot
removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Despite early thrombectomy, a sizeable fraction of acute stroke patients with large vessel
occlusion have poor outcome. The no-reflow phenomenon, ie impaired microvascular …

Ischemic stroke is among the leading causes of disability and death worldwide. In acute
ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary …

Background Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia
are activated and polarized to either the pro-inflammatory M1 phenotype or anti …

Background The urgent challenge for ischemic stroke treatment is the lack of effective
neuroprotectants that target multiple pathological processes. Crebanine, an isoquinoline …

Acute inflammation is a common dangerous component of pathogenesis of many prevalent
conditions with high morbidity and mortality including sepsis, thrombosis, acute respiratory …

Ischemic stroke, prevalent among the elderly, necessitates attention to reperfusion injury
post treatment. Limited drug access to the brain, owing to the blood–brain barrier, restricts …