Noise-induced hearing loss

N Natarajan, S Batts, KM Stankovic - Journal of clinical medicine, 2023 - mdpi.com
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural
hearing loss, after age-related hearing loss, and affects approximately 5% of the world's …

Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus

KS Kraus, B Canlon - Hearing research, 2012 - Elsevier
Acoustic experience such as sound, noise, or absence of sound induces structural or
functional changes in the central auditory system but can also affect limbic regions such as …

Emerging treatments for noise-induced hearing loss

N Oishi, J Schacht - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Approximately 5% of the population worldwide suffers from industrial, military or
recreational noise-induced hearing loss (NIHL) at a great economic cost and detriment to …

Toward cochlear therapies

J Wang, JL Puel - Physiological reviews, 2018 - journals.physiology.org
Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

NF-κB functions in the nervous system: from development to disease

S Mémet - Biochemical pharmacology, 2006 - Elsevier
The transcription factor nuclear factor-κB (NF-κB) is an ubiquitously expressed dimeric
molecule with post-translationally regulated activity. Its role in the immune system and host …

Noise‐induced hearing loss: updates on molecular targets and potential interventions

H Mao, Y Chen - Neural Plasticity, 2021 - Wiley Online Library
Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve
deterioration, resulting in transient or permanent hearing loss depending on the exposure …

Estrogen receptor β protects against acoustic trauma in mice

I Meltser, Y Tahera, E Simpson, M Hultcrantz… - The Journal of clinical …, 2008 - jci.org
The hormone estradiol affects the auditory system both by itself and by its interaction with
neuroprotective factors. In this study, we examined the role of estrogen receptors (ERs) in …

Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma

CT Dinh, S Goncalves, E Bas… - Frontiers in Cellular …, 2015 - frontiersin.org
Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This
review addresses the signaling pathways that are involved in the programmed and necrotic …

The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotective strategies

R N. Abi-Hachem, A Zine… - Recent patents on CNS …, 2010 - benthamdirect.com
One of the causes of sensorineural hearing loss is the loss of auditory hair cells following
exposure to environmental stresses. Auditory hair cell death in response to cochlear trauma …

Dexamethasone protects auditory hair cells against TNFα-initiated apoptosis via activation of PI3K/Akt and NFκB signaling

SM Haake, CT Dinh, S Chen, AA Eshraghi… - Hearing research, 2009 - Elsevier
BACKGROUND: Tumor necrosis factor alpha (TNFα) is associated with trauma-induced
hearing loss. Local treatment of cochleae of trauma-exposed animals with a glucocorticoid is …