Exosomes, which are small extracellular vehicles produced by a variety of cell types, have
emerged as key actors in intercellular communication due to their ability to transport a …

Summary The N 6-methyladenosine (m 6 A) RNA modification is an important regulator of
gene expression. m 6 A is deposited by a methyltransferase complex that includes …

Although the identification of numerous genes involved in neurodevelopmental disorders
(NDDs) has reshaped our understanding of their etiology, there are still major obstacles in …

Importance Polymicrogyria is the most commonly diagnosed cortical malformation and is
associated with neurodevelopmental sequelae including epilepsy, motor abnormalities, and …

Highlights•Overview of convergent disease mechanisms across NDDs identified in 2D & 3D
models.•Discuss therapeutic implications for various ASOs and gene editing …

Mitochondria are critical for brain development and homeostasis. Therefore, pathogenic
variation in the mitochondrial or nuclear genome which disrupts mitochondrial function …

Purpose Widespread application of next-generation sequencing, combined with data
exchange platforms, has provided molecular diagnoses for countless families. To maximize …

The rapid growth of lithium (Li)-related industrial activities and the application of Li-
containing products have become an emerging human health concern. Li has been …

Completion of neuronal migration is critical for brain development. Kif21b is a plus-end-
directed kinesin motor protein that promotes intracellular transport and controls microtubule …

Human disorders of the enteric nervous system (ENS), eg, Hirschsprung's disease, are
rarely associated with major central nervous system involvement. We describe two families …