The effects of mesenchymal stem cells-derived exosomes on metabolic reprogramming in scar formation and wound healing

X Gong, Q Zhao, H Zhang, R Liu, J Wu… - International journal …, 2024 - Taylor & Francis
Pathological scarring results from aberrant cutaneous wound healing due to the
overactivation of biological behaviors of human skin fibroblasts, characterized by local …

Covalent drug discovery using sulfur (VI) fluoride exchange warheads

H Huang, LH Jones - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Introduction Covalent drug discovery has traditionally focused on targeting cysteine, but the
amino acid is often absent in protein binding sites. This review makes the case to move …

Version 4.0 of PaxDb: protein abundance data, integrated across model organisms, tissues, and cell‐lines

M Wang, CJ Herrmann, M Simonovic… - …, 2015 - Wiley Online Library
Protein quantification at proteome‐wide scale is an important aim, enabling insights into
fundamental cellular biology and serving to constrain experiments and theoretical models …

Biological conversion of agricultural residues into microbial proteins for aquaculture using PHA-producing mixed microbial cultures

G Pesante, A Zuliani, E Cannone, F Greco… - Journal of Cleaner …, 2022 - Elsevier
The current trend of increasing human population means that alternative protein sources
need to be sought to avoid malnutrition. Fish is the most efficient protein-rich food, but …

Amino acid variability, tradeoffs and optimality in human diet

Z Dai, W Zheng, JW Locasale - Nature communications, 2022 - nature.com
Studies at the molecular level demonstrate that dietary amino acid intake produces
substantial effects on health and disease by modulating metabolism. However, how these …

Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate

V Kriachkov, AR Ormsby, EP Kusnadi… - Journal of Biological …, 2023 - ASBMB
Hexanucleotide expansion mutations in C9ORF72 are a frequent cause of amyotrophic
lateral sclerosis. We previously reported that long arginine-rich dipeptide repeats (DPRs) …

Yeast has evolved to minimize protein resource cost for synthesizing amino acids

Y Chen, J Nielsen - … of the National Academy of Sciences, 2022 - National Acad Sciences
Proteins, as essential biomolecules, account for a large fraction of cell mass, and thus the
synthesis of the complete set of proteins (ie, the proteome) represents a substantial part of …

Differential amino acid usage leads to ubiquitous edge effect in proteomes across domains of life that can be explained by amino acid secondary structure …

J Morimoto, Z Pietras - Scientific Reports, 2024 - nature.com
Amino acids are the building blocks of proteins and enzymes which are essential for life.
Understanding amino acid usage offers insights into protein function and molecular …

Biosynthetic energy cost for amino acids decreases in cancer evolution

H Zhang, Y Wang, J Li, H Chen, X He, H Zhang… - Nature …, 2018 - nature.com
Rapidly proliferating cancer cells have much higher demand for proteinogenic amino acids
than normal cells. The use of amino acids in human proteomes is largely affected by their …