The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Physiological variability manifests itself via differences in physiological function between
individuals of the same species, and has crucial implications in disease progression and …

The ventricular arrhythmia Torsades de Pointes (TdP) is a common form of drug‐induced
cardiotoxicity, but prediction of this arrhythmia remains an unresolved issue in drug …

Introduction Hypertrophic cardiomyopathy (HCM) is a cause of sudden arrhythmic death, but
the understanding of its pro-arrhythmic mechanisms and an effective pharmacological …

In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …

Acute excessive ethyl alcohol (ethanol) consumption alters cardiac electrophysiology and
can evoke cardiac arrhythmias, eg, in 'holiday heart syndrome'. Ethanol acutely modulates …

The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim
to exploit AF simulations in 800 virtual atria to identify key patient characteristics that guide …