The bromodomain and extraterminal (BET) protein Brd4 recruits transcriptional regulatory
complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

The human genome contains thousands of long non-coding RNAs, but specific biological
functions and biochemical mechanisms have been discovered for only about a dozen,,,,–. A …

Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …

As a result of recent improvements in mass spectrometry (MS), there is increased interest in
data-independent acquisition (DIA) strategies in which all peptides are systematically …

Abstract N 6‐methyladenosine (m6A) is a highly dynamic RNA modification that has recently
emerged as a key regulator of gene expression. While many m6A modifications are installed …

Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited …

We present'significance analysis of interactome'(SAINT), a computational tool that assigns
confidence scores to protein-protein interaction data generated using affinity purification …

Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from
proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their …

Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for
the identification of protein-protein interactions. However, for any given protein of interest …