The landscape of the mesenchymal signature in brain tumours
The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …
Phenotypic screening in cancer drug discovery—past, present and future
There has been a resurgence of interest in the use of phenotypic screens in drug discovery
as an alternative to target-focused approaches. Given that oncology is currently the most …
as an alternative to target-focused approaches. Given that oncology is currently the most …
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
A three-dimensional organoid culture system derived from human glioblastomas recapitulates the hypoxic gradients and cancer stem cell heterogeneity of tumors …
Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem
cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell …
cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell …
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition
Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis.
Here, we demonstrate that these histological features are associated with distinct …
Here, we demonstrate that these histological features are associated with distinct …
Clinical significance of extracellular vesicles in plasma from glioblastoma patients
Purpose: Glioblastoma (GBM) is the most common primary brain tumor. The identification of
blood biomarkers reflecting the tumor status represents a major unmet need for optimal …
blood biomarkers reflecting the tumor status represents a major unmet need for optimal …
[HTML][HTML] Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …
Nitrogen‐Vacancy‐Rich VN Clusters Embedded in Carbon Matrix for High‐Performance Zinc Ion Batteries
Vanadium nitride (VN) is a potential cathode material with high capacity and high energy
density for aqueous zinc batteries (AZIBs). However, the slow kinetics resulting from the …
density for aqueous zinc batteries (AZIBs). However, the slow kinetics resulting from the …
Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma
Purpose: Glioblastoma is the most frequent and lethal primary brain tumor. Development of
novel therapies relies on the availability of relevant preclinical models. We have established …
novel therapies relies on the availability of relevant preclinical models. We have established …
[HTML][HTML] Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …