Recent advances in in-process characterization of suspensions and slurries

DM Scott - Powder Technology, 2022 - Elsevier
A comprehensive literature review was conducted on new and emerging methods for in-
process characterization of suspensions and slurries. The 152 publications reviewed here …

Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

CJ Brown, T McGlone, S Yerdelen… - … Systems Design & …, 2018 - pubs.rsc.org
Continuous manufacturing is widely used for the production of commodity products.
Currently, it is attracting increasing interest from the pharmaceutical industry and regulatory …

Optimal feedback control of batch self-assembly processes using dynamic programming

MA Grover, DJ Griffin, X Tang, Y Kim… - Journal of Process …, 2020 - Elsevier
This paper reviews a previously-reported methodology for establishing feedback control of
self-assembly. The methodology combines dimension reduction, supervised learning, and …

Identification of pollen taxa by different microscopy techniques

M Pospiech, Z Javůrková, P Hrabec, P Štarha… - PLoS …, 2021 - journals.plos.org
Melissopalynology is an important analytical method to identify botanical origin of honey.
Pollen grain recognition is commonly performed by visual inspection by a trained person. An …

Protein nucleation and crystallization process with process analytical Technologies in a batch crystallizer

W Tian, W Li, H Yang - Crystal Growth & Design, 2023 - ACS Publications
Protein crystallization has drawn great attention to replacing the traditional downstream
processing for protein-based pharmaceuticals due to its advantages in stability, storage, and …

Sedimentation and consolidation of different density aggregates formed by polymer-bridging flocculation

FA Benn, PD Fawell, J Halewood, PJ Austin… - Chemical Engineering …, 2018 - Elsevier
There are numerous models of sedimentation in fine particle suspensions, derived from or
validated with physical measurements. Such models could be applied to optimise and …

Evaluation of focused beam reflectance measurement (FBRM) for monitoring and predicting the crystal size of carbamazepine in crystallization processes

D Acevedo, WL Wu, X Yang, N Pavurala… - …, 2021 - pubs.rsc.org
Pharmaceutical crystallization has an impact on the properties of active pharmaceutical
ingredients as it determines the purity, crystal size distribution and polymorphs, among other …

Experimental implementation of a Quality-by-Control (QbC) framework using a mechanistic PBM-based nonlinear model predictive control involving chord length …

B Szilágyi, Á Borsos, K Pal, ZK Nagy - Chemical Engineering Science, 2019 - Elsevier
Abstract l-ascorbic acid is synthetized in large industrial scale from glucose and marketed as
an immune system strengthening agent and anti-oxidant ingredient. The overall yield of …

[HTML][HTML] Integration of in situ imaging and chord length distribution measurements for estimation of particle size and shape

OS Agimelen, A Jawor-Baczynska, J McGinty… - Chemical Engineering …, 2016 - Elsevier
Efficient processing of particulate products across various manufacturing steps requires that
particles possess desired attributes such as size and shape. Controlling the particle …

Gravity as a Knob for Tuning Particle Size Distributions of Small Molecules

K Pal, A Radocea - Crystal Growth & Design, 2024 - ACS Publications
Pharmaceutical research and development and manufacturing can widely benefit from a
microgravity environment. Although the use of microgravity to improve control over the size …