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Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
Role of apoptosis in disease
B Favaloro, N Allocati, V Graziano, C Di Ilio… - Aging (Albany …, 2012 - pmc.ncbi.nlm.nih.gov
Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …
described. In this review we will focus on classic caspase-dependent apoptosis and its …
Lentiviral vector bioprocessing
C Perry, ACME Rayat - Viruses, 2021 - mdpi.com
Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …
cells and are now commonly utilised within the growing field of cell and gene therapy for the …
[HTML][HTML] Pan-retroviral nucleocapsid-mediated phase separation regulates genomic RNA positioning and trafficking
The duality of liquid-liquid phase separation (LLPS) of cellular components into
membraneless organelles defines the nucleation of both normal and disease processes …
membraneless organelles defines the nucleation of both normal and disease processes …
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis
M Février, K Dorgham, A Rebollo - Viruses, 2011 - pmc.ncbi.nlm.nih.gov
Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the
gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and …
gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and …
Mechanisms of HIV-associated lymphocyte apoptosis: 2010
NW Cummins, AD Badley - Cell death & disease, 2010 - nature.com
The inevitable decline of CD4T cells in untreated infection with the Human
immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell …
immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell …
New developments in lentiviral vector design, production and purification
MM Segura, M Mangion, B Gaillet… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Lentiviruses are a very potent class of viral vectors for which there is presently a
rapidly growing interest for a number of gene therapy. However, their construction …
rapidly growing interest for a number of gene therapy. However, their construction …
Toxin-based therapeutic approaches
Protein toxins confer a defense against predation/grazing or a superior pathogenic
competence upon the producing organism. Such toxins have been perfected through …
competence upon the producing organism. Such toxins have been perfected through …
Prime, shock, and kill: priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size
NW Cummins, AM Sainski, H Dai… - Journal of …, 2016 - journals.asm.org
Understanding how some HIV-infected cells resist the cytotoxicity of HIV replication is crucial
to enabling HIV cure efforts. HIV killing of CD4 T cells that replicate HIV can involve HIV …
to enabling HIV cure efforts. HIV killing of CD4 T cells that replicate HIV can involve HIV …
Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition
NW Cummins, AM Sainski-Nguyen… - Journal of …, 2017 - journals.asm.org
Decay of the HIV reservoir is slowed over time in part by expansion of the pool of HIV-
infected cells. This expansion reflects homeostatic proliferation of infected cells by …
infected cells. This expansion reflects homeostatic proliferation of infected cells by …