Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Most organisms experience changes in regenerative abilities through their lifespan. During
aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that …

Why mammals have poor regenerative ability has remained a long-standing question in
biology. In regenerating vertebrates, injury can induce a process known as epimorphic …

The ability of vertebrates to regenerate amputated appendages is increasingly well-
understood at the cellular level. Cells mediating an innate immune response and …

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

The newt, a urodele amphibian, is able to repeatedly regenerate its limbs throughout its
lifespan, whereas other amphibians deteriorate or lose their ability to regenerate limbs after …

Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …

The evolution of regenerative capacity in multicellular animals represents one of the most
complex and intriguing problems in biology. How could such a seemingly advantageous trait …

The ability to regenerate amputated or injured tissues and organs is a fascinating property
shared by several invertebrates and, interestingly, some vertebrates. The mechanism of …

The regenerative capacity varies significantly among the animal kingdom. Successful
regeneration program in some animals results in the functional restoration of tissues and lost …