Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Centromeres are specialized chromosome loci that seed the kinetochore, a large protein
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …

Defining the genes that are essential for cellular proliferation is critical for understanding
organismal development and identifying high-value targets for disease therapies. However …

Mutations in any of at least sixteen FANC genes (FANCA–Q) cause Fanconi anemia, a
disorder characterized by sensitivity to DNA interstrand crosslinking agents. The clinical …

The basic determinant of chromosome inheritance, the centromere, is specified in many
eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast …