Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
[HTML][HTML] Oxidative stress: a unifying paradigm in hypertension
The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …
and pathophysiologic factors that influence many regulatory systems. Hypertension is …
Pharmacological inhibition of the nod-like receptor family pyrin domain containing 3 inflammasome with MCC950
SE Corcoran, R Halai, MA Cooper, C Page - Pharmacological reviews, 2021 - Elsevier
Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical
activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven …
activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven …
Inflammation as a regulator of the renin-angiotensin system and blood pressure
Abstract Purpose of Review Mechanisms facilitating progression of hypertension via cross
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …
Underlying vulnerabilities to the cytokine storm and adverse COVID-19 outcomes in the aging immune system
LS Nidadavolu, JD Walston - The Journals of Gerontology …, 2021 - academic.oup.com
Older adults are far more vulnerable to adverse health outcomes and mortality after
contracting COVID-19. There are likely multiple age-related biological, clinical, and …
contracting COVID-19. There are likely multiple age-related biological, clinical, and …
MCC950, the selective inhibitor of nucleotide oligomerization domain-like receptor protein-3 inflammasome, protects mice against traumatic brain injury
Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …
AMP-activated protein kinase regulation of the NLRP3 inflammasome during aging
MD Cordero, MR Williams, B Ryffel - Trends in Endocrinology & Metabolism, 2018 - cell.com
The NLRP3 inflammasome has recently emerged as an unexpected marker of stress and
metabolic risk and has also been implicated in the development of major aging-related …
metabolic risk and has also been implicated in the development of major aging-related …
Cellular senescence in kidney fibrosis: pathologic significance and therapeutic strategies
J Xu, L Zhou, Y Liu - Frontiers in pharmacology, 2020 - frontiersin.org
Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent
globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a …
globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a …
Rodent models of hypertension
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …
disease. As a multifactorial and systemic disease that involves multiple organs and systems …