The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Exomeres are a recently discovered type of extracellular nanoparticle with no known
biological function. Herein, we describe a simple ultracentrifugation-based method for …

The full potential of ionizable lipid nanoparticles (LNPs) as an in vivo nucleic acid delivery
platform has not yet been realized given that LNPs primarily accumulate in the liver following …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of
small-sized stem cell populations that continuously generate new progeny to replace lost …

The rapidly self-renewing epithelium in the mammalian intestine is maintained by
multipotent intestinal stem cells (ISCs) located at the bottom of the intestinal crypt that are …

Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of
intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in …

Despite a well-established role for the epidermal growth factor receptor (EGFR) in
tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We …

Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …