Myopia
Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …
forms the major node of cellular and organismal defense against oxidative and electrophilic …
Role of nrf2 in oxidative stress and toxicity
Q Ma - Annual review of pharmacology and toxicology, 2013 - annualreviews.org
Organismal life encounters reactive oxidants from internal metabolism and environmental
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …
Chalcone: a privileged structure in medicinal chemistry
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
Glutathione transferases
JD Hayes, JU Flanagan… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …
Cancer chemoprevention with dietary phytochemicals
YJ Surh - Nature Reviews Cancer, 2003 - nature.com
Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis.
Numerous phytochemicals derived from edible plants have been reported to interfere with a …
Numerous phytochemicals derived from edible plants have been reported to interfere with a …
Role of oxidative modifications in atherosclerosis
R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
Update 1 of: electrophilicity index
Chemistry is the science of bond making and bond breaking. A thorough knowledge of these
processes in the course of the chemical reaction lies at the heart of any reaction mechanism …
processes in the course of the chemical reaction lies at the heart of any reaction mechanism …
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova, WD Holtzclaw… - Proceedings of the …, 2002 - National Acad Sciences
Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against
the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently …
the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently …
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative …
A common feature of diverse chemopreventive agents is the ability to activate expression of
a genetic program that protects cells from reactive chemical species that, if left unchecked …
a genetic program that protects cells from reactive chemical species that, if left unchecked …