PHLP** the script: emerging roles of PHLPP phosphatases in cell signaling
Whereas protein kinases have been successfully targeted for a variety of diseases, protein
phosphatases remain an underutilized therapeutic target, in part because of incomplete …
phosphatases remain an underutilized therapeutic target, in part because of incomplete …
[HTML][HTML] Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma
Glioblastoma is the most common and aggressive primary tumor of the central nervous
system with poor outcome. Current gold standard treatment is surgical resection followed by …
system with poor outcome. Current gold standard treatment is surgical resection followed by …
LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis
S Li, RC He, SG Wu, Y Song, KL Zhang… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Increasing evidence suggests that long noncoding RNAs play significant
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity
In 2021, the World Health Organization reclassified glioblastoma, the most common form of
adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade …
adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade …
KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma
H Cai, J Liang, Y Jiang, Z Wang, H Li, W Wang… - Journal of Experimental …, 2024 - Springer
Background Head and neck squamous carcinoma (HNSCC) is known for its high
aggressiveness and susceptibility to cervical lymph node metastasis, which greatly …
aggressiveness and susceptibility to cervical lymph node metastasis, which greatly …
The EGFRvIII transcriptome in glioblastoma: A meta-omics analysis
Y Hoogstrate, SA Ghisai, M de Wit, I de Heer… - Neuro …, 2022 - academic.oup.com
Background EGFR is among the genes most frequently altered in glioblastoma, with exons 2-
7 deletions (EGFRvIII) being among its most common genomic mutations. There are …
7 deletions (EGFRvIII) being among its most common genomic mutations. There are …
Development of a novel prognostic signature derived from super-enhancer-associated gene by machine learning in head and neck squamous cell carcinoma
A Wang, H **a, J Li, P Diao, J Cheng - Oral Oncology, 2024 - Elsevier
Dysregulated super-enhancer (SE) results in aberrant transcription that drives cancer
initiation and progression. SEs have been demonstrated as novel promising …
initiation and progression. SEs have been demonstrated as novel promising …
Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population
J Hao, C Huang, W Zhao, L Zhao, X Hu… - NeuroMolecular …, 2024 - Springer
Glioma is the most common primary intracranial tumor with high mortality and poor
prognosis. The purpose of this study was to investigate how single-nucleotide …
prognosis. The purpose of this study was to investigate how single-nucleotide …
Super enhancer loci of EGFR regulate EGFR variant 8 through enhancer RNA and strongly associate with survival in HNSCCs
SR Chakkarappan, KV Umadharshini… - Molecular Genetics and …, 2024 - Springer
Epidermal growth factor receptor (EGFR) has been shown to be overexpressed in human
cancers due to mutation, amplification, and epigenetic hyperactivity, which leads to …
cancers due to mutation, amplification, and epigenetic hyperactivity, which leads to …
ETV5 facilitates tumor progression in head‐neck squamous cell carcinoma
S Yu, Z Ma, T Chen, H Wang, Q Yao, J Li… - Oral …, 2024 - Wiley Online Library
Objective E26 transformation‐specific (ETS) factors have emerged as key mediators
underlying human tumorigenesis. Here, we sought to characterize the expression pattern …
underlying human tumorigenesis. Here, we sought to characterize the expression pattern …