Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Phosphoinositides (PIs) are phospholipids that perform crucial cell functions, ranging from
cell migration and signaling to membrane trafficking, by serving as signposts of …

Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …

Protein recycling through the endolysosomal system relies on molecular assemblies that
interact with cargo proteins, membranes, and effector molecules. Among them, the …

The actin cytoskeleton is indispensable for several cellular processes, including migration,
morphogenesis, polarized growth, endocytosis, and phagocytosis. The organization and …

Actin cytoskeleton dynamics depend on a tight regulation of actin filament formation from an
intracellular pool of monomers, followed by their linkage to each other or to cell membranes …

Clathrin-mediated endocytosis occurs via the assembly of clathrin-coated pits (CCPs) that
invaginate and pinch off to form clathrin-coated vesicles (CCVs). It is well known that adaptor …

An increasing corpus of research has demonstrated that membrane shape, generated either
by the external environment of the cell or by intrinsic mechanisms such as cytokinesis and …

During clathrin-mediated endocytosis (CME), flat plasma membrane is remodeled to
produce nanometer-scale vesicles. The mechanisms underlying this remodeling are not …