Thermoresponsive interfaces obtained using poly (N-isopropylacrylamide)-based copolymer for bioseparation and tissue engineering applications

K Nagase - Advances in Colloid and Interface Science, 2021 - Elsevier
Abstract Poly (N-isopropylacrylamide)(PNIPAAm) is the most well-known and widely used
stimuli-responsive polymer in the biomedical field owing to its ability to undergo temperature …

[HTML][HTML] Progress in ATRP-derived materials for biomedical applications

MK Yazdi, P Zarrintaj, MR Saeb, M Mozafari… - Progress in Materials …, 2024 - Elsevier
The continuing wave of technological breakthroughs and advances is critical for engineering
well-defined materials, particularly biomaterials, with tailored microstructure and properties …

Poly(N-isopropylacrylamide)-based temperature- and pH-responsive polymer materials for application in biomedical fields

Y Hiruta - Polymer Journal, 2022 - nature.com
The synthesis and application of stimuli-responsive polymer materials have been
extensively studied. Among stimuli-responsive polymers, thermoresponsive poly (N …

[HTML][HTML] Thermoresponsive block-copolymer brush-modified interfaces for effective fabrication of hepatocyte sheets

K Nagase, M Nagaoka, J Matsuda, N Kojima - Materials & Design, 2024 - Elsevier
Hepatic tissue engineering has been investigated for the treatment of liver disease. One
promising tissue is the hepatocyte sheet, cultured in temperature-responsive cell culture …

[HTML][HTML] bFGF-releasing biodegradable nanoparticles for effectively engrafting transplanted hepatocyte sheet

K Nagase, M Nagaoka, Y Nakano, R Utoh - Journal of Controlled Release, 2024 - Elsevier
Hepatic tissue engineering has been applied for the treatment of intractable liver diseases,
and hepatocyte sheets are promising for this purpose. However, hepatocyte sheets have …

Brush-like polymers: design, synthesis and applications

L Yin, L Liu, N Zhang - Chemical Communications, 2021 - pubs.rsc.org
With the development of controlled polymerisation, almost all polymerisation strategies have
been successfully transplanted to surface-initiated polymerisation. The resulting polymer …

Thermoresponsive mixed polymer brush to effectively control the adhesion and separation of stem cells by altering temperature

K Nagase, H Wakayama, J Matsuda, N Kojima… - Materials Today Bio, 2023 - Elsevier
During the last few decades, thermoresponsive materials for modulating cell adhesion have
been investigated for the application of tissue engineering. In this study, we developed …

Umbilical cord-derived mesenchymal stem cell sheets transplanted subcutaneously enhance cell retention and survival more than dissociated stem cell injections

M Nakao, M Matsui, K Kim, N Nishiyama… - Stem Cell Research & …, 2023 - Springer
Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have
recently attracted attention as an alternative approach to injected cell suspensions for stem …

[HTML][HTML] Thermoresponsive bio-affinity interfaces for temperature-modulated selective capture and release of targeted exosomes

K Nagase, K Yamazaki, Y Maekawa, H Kanazawa - Materials Today Bio, 2023 - Elsevier
The existing methods for exosome isolation, such as ultracentrifugation, size exclusion, and
affinity separation, suffer from some limitations. Herein, we aimed to develop temperature …

Hydration and dehydration behaviors of poly (N-isopropylacrylamide)-grafted silica beads

K Nagase, J Matsuda, A Takeuchi, Y Ikemoto - Surfaces and Interfaces, 2023 - Elsevier
The use of poly (N-isopropyl acrylamide)(PNIPAAm) in thermoresponsive interfaces for
biomedical applications has been extensively investigated. Understanding the hydration …