The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers
worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic …

Cancer is often viewed as a caricature of normal developmental processes, but the extent to
which its cellular heterogeneity truly recapitulates multilineage differentiation processes of …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Cancer remains one of the leading lethal diseases worldwide. Identifying biomarkers of
cancers might provide insights into the strategies for the development of novel targeted anti …

Over recent decades we have witnessed a shift in the anatomical distribution of gastric
cancer (GC), which increasingly originates from the proximal stomach near the junction with …

Recently, there has been resurgence of interest in the question of small intestinal stem cells,
their precise location and numbers in the crypts. In this article, we attempt to re‐assess the …

BACKGROUND & AIMS: Long-term propagation of human colonic epithelial cells (HCEC) of
adult origin has been a challenge; currently used HCEC lines are of malignant origin and/or …

LGR5 is known to be a stem cell marker in the murine small intestine and colon, however the
localization of LGR5 in human adenoma samples has not been examined in detail and …

It is thought that small intestinal epithelia (IE) undergo continuous self-renewal primarily due
to their population of undifferentiated stem cells. These stem cells give rise to transit …