Engineered cell and tissue models of pulmonary fibrosis

A Sundarakrishnan, Y Chen, LD Black… - Advanced drug delivery …, 2018 - Elsevier
Pulmonary fibrosis includes several lung disorders characterized by scar formation and
Idiopathic Pulmonary Fibrosis (IPF) is a particularly severe form of pulmonary fibrosis of …

[HTML][HTML] Tissue engineering: understanding the role of biomaterials and biophysical forces on cell functionality through computational and structural biotechnology …

N Almouemen, HM Kelly, C O'leary - Computational and structural …, 2019 - Elsevier
Within the past 25 years, tissue engineering (TE) has grown enormously as a science and
as an industry. Although classically concerned with the recapitulation of tissue and organ …

Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus

J Berg, T Hiller, MS Kissner, TH Qazi, GN Duda… - Scientific reports, 2018 - nature.com
Bioprinting is a new technology, which arranges cells with high spatial resolution, but its
potential to create models for viral infection studies has not yet been fully realized. The …

Collagen-based biomaterials for tissue regeneration and repair

EJ Sheehy, GM Cunniffe, FJ O'Brien - Peptides and proteins as biomaterials …, 2018 - Elsevier
Collagen is the main component of the extracellular matrix and has shown great promise as
a biomaterial for tissue engineering and regenerative medicine applications. This chapter …

Synthesis of Alginate/Collagen Bioink for Bioprinting Respiratory Tissue Models

A Zimmerling, Y Zhou, X Chen - Journal of Functional Biomaterials, 2024 - mdpi.com
Synthesis of bioinks for bioprinting of respiratory tissue requires considerations related to
immunogenicity, mechanical properties, printability, and cellular compatibility. Biomaterials …

The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold

C O'Leary, B Cavanagh, RE Unger, CJ Kirkpatrick… - Biomaterials, 2016 - Elsevier
Today, chronic respiratory disease is one of the leading causes of mortality globally.
Epithelial dysfunction can play a central role in its pathophysiology. The development of …

[HTML][HTML] Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics

T Chen, Z Zhang, D Weng, LQ Lu, XY Wang, M **ng… - Bioactive Materials, 2021 - Elsevier
Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available
therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of …

The Fabrication and in vitro Evaluation of Retinoic Acid-Loaded Electrospun Composite Biomaterials for Tracheal Tissue Regeneration

C O'Leary, L Soriano, A Fagan-Murphy… - … in bioengineering and …, 2020 - frontiersin.org
Although relatively rare, major trauma to the tracheal region of the airways poses a
significant clinical challenge with few effective treatments. Bioengineering and regenerative …

Development of a nanoparticle system for controlled release in bioprinted respiratory scaffolds

A Zimmerling, C Sunil, Y Zhou, X Chen - Journal of Functional …, 2024 - mdpi.com
The use of nanoparticle systems for the controlled release of growth factors is a promising
approach to mimicking of the biochemical environment of native tissues in tissue …

Mesenchymal stem cell administration in patients with chronic obstructive pulmonary disease: state of the science

SL Cheng, CH Lin, CL Yao - Stem Cells International, 2017 - Wiley Online Library
Patients with chronic obstructive pulmonary disease (COPD) have chronic, irreversible
airway inflammation; currently, there is no effective or curative treatment and the main goals …