Vaccinia virus produces four different types of virion from each infected cell called
intracellular mature virus (IMV), intracellular enveloped virus (IEV), cell-associated …

Large DNA viruses defend against hostile assault executed by the host immune system by
producing an array of gene products that systematically sabotage key components of the …

Human monkeypox was first recognized outside Africa in 2003 during an outbreak in the
USA that was traced to imported monkeypox virus (MPXV)-infected West African rodents …

For many viruses, one or two proteins enable cell binding, membrane fusion and entry. The
large number of proteins employed by poxviruses is unprecedented and may be related to …

The eradication of smallpox, one of the great triumphs of medicine, was accomplished
through the prophylactic administration of live vaccinia virus, a comparatively benign relative …

Vaccinia virus is the smallpox vaccine. It is the most intensively studied poxvirus, and its
study has provided important insights about virus replication in general and the interactions …

Microtubule-mediated transport of macromolecules and organelles (also known as" cargo")
is essential for cells to function. Deficiencies in cytoplasmic transport are frequently …

An immunodominant antigen, p35, is expressed on the envelope of intracellular mature
virions (IMV) of vaccinia virus. p35 is encoded by the viral late gene H3L, but its role in the …

Studies of the actin-based motility of the intracellular pathogens Listeria monocytogenes and
Shigella flexneri have provided important insight into the events occurring at the leading …

The study of poxvirus entry and membrane fusion has been invigorated by new biochemical
and microscopic findings that lead to the following conclusions:(1) the surface of the mature …