RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of
naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal …

Ribosomes are translational machineries that catalyse protein synthesis. Ribosome
structures from various species are known at the atomic level, but obtaining the structure of …

This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …

The ribosome is a molecular machine responsible for protein synthesis and a major target
for small-molecule inhibitors. Compared to the wealth of structural information available on …

In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …

Protein synthesis in all cells is carried out by macromolecular machines called ribosomes.
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …