The metabolism of tryptophan is intimately associated with the differential regulation of
diverse physiological processes, including in the regulation of responses to severe acute …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …

Microplastic particles (MP) has been detected in the environment widespread. Human
beings are inevitably exposed to MP via multiple routines. However, the hazard …

Wastewater treatment plants (WWTPs) serve as the main destination of many wastes
containing per-and polyfluoroalkyl substances (PFAS). Here, we investigated the occurrence …

In this work, we have developed and tested a dry powder form of niclosamide made by thin-
film freezing (TFF) and administered it by inhalation to rats and hamsters to gather data …

Superfamily of cytochromes P450 (CYPs) is composed of heme-thiolate-containing
monooxygenase enzymes, which play crucial roles in the biosynthesis, bioactivation, and …

In recent years, natural products have gradually become an important source for new drug
development due to their advantages of multi-components, multi-targets, and good safety …

Significance: Targeted cancer therapy with minimal off-target consequences has shown
promise for some cancer types. Although cytochrome P450 (CYP) consists of 18 families …

This chapter introduces xenobiotic metabolism (in this chapter, the terms “xenobiotic
metabolism” and “xenobiotic-metabolizing enzyme” will be used in preference to “drug …

Endoplasmic reticulum‐resident proteins (ERPs) are crucial for maintaining cellular
homeostasis and are tightly associated with the onset and progression of various diseases …