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Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
The dark proteome: translation from noncanonical open reading frames
Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …
the genome. In particular, these studies revealed widespread unannotated open reading …
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
[HTML][HTML] A high-resolution map of human RNA translation
Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …
encode microproteins, yet their genome-wide identification has been challenging. We …
Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells
Cellular responses to TNF are inherently heterogeneous within an isogenic cell population
and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF …
and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF …
Overlap** genes in natural and engineered genomes
Modern genome-scale methods that identify new genes, such as proteogenomics and
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …
Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity
Y Takakura, M Machida, N Terada, Y Katsumi… - Nature …, 2024 - nature.com
Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial
damage. However, stress-independent autophagy is activated by unclear mechanisms in …
damage. However, stress-independent autophagy is activated by unclear mechanisms in …
[HTML][HTML] Profiling mouse brown and white adipocytes to identify metabolically relevant small ORFs and functional microproteins
Microproteins (MPs) are a potentially rich source of uncharacterized metabolic regulators.
Here, we use ribosome profiling (Ribo-seq) to curate 3,877 unannotated MP-encoding small …
Here, we use ribosome profiling (Ribo-seq) to curate 3,877 unannotated MP-encoding small …
ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs
Identifying open reading frames (ORFs) being translated is not a trivial task. ProTInSeq is a
technique designed to characterize proteomes by sequencing transposon insertions …
technique designed to characterize proteomes by sequencing transposon insertions …
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48
Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …