Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier
of the nuclear pore complex and deliver the genome directly into the nucleus,. Remarkably …

Host proteins are essential for HIV entry and replication and can be important nonviral
therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified …

Exosomes represent an attractive vehicle for the delivery of biomolecules. However,
mechanisms for loading functional molecules into exosomes are relatively unexplored. Here …

Host dependency factors that are required for influenza A virus infection may serve as
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …

Animal cells harbour multiple innate effector mechanisms that inhibit virus replication. For
the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include …

Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on
the host cellular machinery to replicate. Identifying which host proteins and complexes come …

Live-cell imaging has revealed unexpected features of gene expression. Here using
improved single-molecule RNA microscopy, we show that synthesis of HIV-1 RNA is …