Neuropharmacology of antiseizure drugs

T Hakami - Neuropsychopharmacology reports, 2021 - Wiley Online Library
Abstract Background Antiseizure drugs (ASDs) are the primary therapy for epilepsy, with
more than 20 drugs introduced into clinical practice to date. These drugs are typically …

Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)

M Bialer, SI Johannessen, HJ Kupferberg, RH Levy… - Epilepsy research, 2007 - Elsevier
The Eigth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT VII, took place in
Sitges, Barcelona from the 10th to 14th September, 2006. Basic scientists, clinical …

Morphine, gabapentin, or their combination for neuropathic pain

I Gilron, JM Bailey, D Tu, RR Holden… - … England Journal of …, 2005 - Mass Medical Soc
Background The available drugs to treat neuropathic pain have incomplete efficacy and
dose-limiting adverse effects. We compared the efficacy of a combination of gabapentin and …

The efficacy of the ketogenic diet—1998: a prospective evaluation of intervention in 150 children

JM Freeman, EPG Vining, DJ Pillas, PL Pyzik… - …, 1998 - publications.aap.org
Objective. The ketogenic diet is a high-fat, low-protein, low-carbohydrate diet developed in
the 1920s for the treatment of children with difficult to control seizures. Despite advances in …

Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy

F Lefevre, N Aronson - Pediatrics, 2000 - publications.aap.org
Objectives. To systematically review and synthesize the available evidence on the efficacy of
the ketogenic diet in reducing seizure frequency for children with refractory epilepsy. Data …

Adjunctive lacosamide for partial‐onset seizures: efficacy and safety results from a randomized controlled trial

P Halász, R Kälviäinen… - …, 2009 - Wiley Online Library
Purpose: To evaluate the efficacy and safety of lacosamide (200 and 400 mg/day) when
added to one to three concomitant antiepileptic drugs (AEDs) in patients with uncontrolled …

Epilepsy after the first drug fails: substitution or add-on?

P Kwan, MJ Brodie - Seizure, 2000 - Elsevier
When and how a combination of antiepileptic drugs (AEDs) should be used in patients
unresponsive to monotherapy is not known. We followed up prospectively 248 patients in …

Clinical aspects and biological bases of drug-resistant epilepsies

G Regesta, P Tanganelli - Epilepsy research, 1999 - Elsevier
The definition of drug-resistant epilepsy (DRE) is elusive and still controversial owing to
some unresolved questions such as: how many drugs should be tried before a patient is …

The adverse event profile of pregabalin: A systematic review and meta‐analysis of randomized controlled trials

G Zaccara, P Gangemi, P Perucca, L Specchio - Epilepsia, 2011 - Wiley Online Library
Purpose: Despite the widespread use of antiepileptic drugs (AEDs) across different
neurologic and psychiatric disorders, no study has systematically reviewed all available …

Cognitive side-effects of antiepileptic drugs in children

DM Ijff, AP Aldenkamp - Handbook of clinical neurology, 2013 - Elsevier
Although the causes of cognitive impairment in patients with epilepsy have not been
completely elucidated, three factors are clearly involved: the underlying etiology of epilepsy …