A lack of in vitro models that robustly represent the complex cellular pathologies underlying
neurodegeneration has resulted in a translational gap between in vitro and in vivo results …

Disease models enable researchers to investigate, test, and identify therapeutic targets that
would alter the patients' disease condition and improve quality of life. Advances in genetic …

Drug-induced seizure liability is a significant safety issue and the basis for attrition in drug
development. Occurrence in late development results in increased costs, human risk, and …

Calcium oscillations in primary neuronal cultures and iPSCs have been employed to
investigate arrhythmogenicity and epileptogenicity in drug development. Previous studies …

With the advent of molecular and cellular toxicology, the field of drug safety evaluation has
been undergoing an important paradigm shift, which has recently been further incentivized …

The assessment of neurotoxicity for environmental chemicals is of utmost importance in
ensuring public health and environmental safety. Multielectrode array (MEA) technology has …

Seizure is among the most severe FDA black box warnings of neurotoxicity reported on drug
labels. Gaining a better mechanistic understanding of off-targets causative of seizure will …

Increasing the use of microphysiological systems (MPS) in Three Rs and regulatory
applications is a nuanced but important goal, which would also help increase their scientific …

Abstract Human induced Pluripotent Stem Cell (hiPSC) derived neural cells offer great
potential for modelling neurological diseases and toxicities and have found application in …

The iPSC-derived 3D models are considered to be a connective link between 2D culture
and in vivo studies. However, the sensitivity of such 3D models is yet to be established. We …