This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell
types of an adult organism. This property can be captured indefinitely through derivation of …

Recent advances in human blastoids have opened new avenues for modeling early human
development and implantation. One limitation of our first protocol for human blastoid …

Gynecologic cancers involve the female genital organs, such as the vulva, vagina, cervix,
endometrium, ovaries, and fallopian tubes. The occurrence and frequency of gynecologic …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …

The activation of STAT3 by tyrosine phosphorylation, essential for normal development and
for a normal inflammatory response to invading pathogens, is kept in check by negative …

Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-
renew by means of a controlled process of activation and proliferation of tissue-resident …

The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst,
are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how …

Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …