Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

The astronomical increase of the world's aged population is associated with the increased
prevalence of neurodegenerative diseases, heightened disability, and extremely high costs …

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
around the world. Even though the causes of AD are not completely understood due to its …

Currently, there is no known cure for neurodegenerative disease. However, the available
therapies aim to manage some of the symptoms of the disease. Human neurodegenerative …

Alzheimer's disease is pathologically characterized by abnormal accumulation of amyloid-
beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and …

A series of previously synthesized conjugates of tacrine and salicylamide was extended by
varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize …

Experimental studies support the discussion of the use of bioactive products of natural
products as novel antioxidants sources of neuroprotection against neurodegeneration …

Herein the effects of three platinum complexes, namely (SP-4-2)-(2, 2′-bipyridine)
dichloridoplatinum (II), Pt-bpy,(SP-4-2)-dichlorido (1, 10-phenanthroline) platinum (II), Pt …