Interplay between platelets and coagulation: from protective haemostasis to pathological arterial thrombosis
G Vilahur, V Fuster - European Heart Journal, 2025 - academic.oup.com
Haemostasis refers to the physiological process aimed at repairing vessel injury and
preventing bleeding. It involves four interlinked stages culminating in the formation of a …
preventing bleeding. It involves four interlinked stages culminating in the formation of a …
Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy
M Yan, Z Wang, Z Qiu, Y Cui, Q **ang - Biomarker Research, 2024 - Springer
Platelets are essential for blood clotting and maintaining normal hemostasis. In pathological
conditions, platelets are increasingly recognized as crucial regulatory factors in various …
conditions, platelets are increasingly recognized as crucial regulatory factors in various …
The quest for the holy grail in antithrombotic therapy: revitalized hope for platelet GPVI as a safe and effective antithrombotic target
Collagen binds to the platelet GPVI receptor and triggers platelet activation via the Fc
receptor γ (FcRγ) chain which contains an immunoreceptor tyrosine-based activation motif …
receptor γ (FcRγ) chain which contains an immunoreceptor tyrosine-based activation motif …
Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets
Lesioned fascicles (LFs) in the sciatic nerves of individuals with diabetic neuropathy (DN)
correlate with clinical symptom severity. This study aimed to characterize the structural and …
correlate with clinical symptom severity. This study aimed to characterize the structural and …
Tracking GP VI in Abdominal Aortic Aneurysms: A Crucial Pathological Link?
E Mammadova-Bach, A Braun - Arteriosclerosis, Thrombosis, and …, 2024 - ahajournals.org
AAAs are vascular disorders characterized by the dilation of the abdominal aorta, associated
with high morbidity. 2 The destruction of the medial layer of the aorta causes irreversible …
with high morbidity. 2 The destruction of the medial layer of the aorta causes irreversible …
PROTACs in platelets: emerging antithrombotic strategies and future perspectives
JS Trory, J Vautrinot, CJ May, I Hers - Current Opinion in …, 2025 - journals.lww.com
Platelets are susceptible to targeted protein degradation by CRBN ligand-based PROTACs
and have limited ability to resynthesise proteins, ensuring long-term downregulation of …
and have limited ability to resynthesise proteins, ensuring long-term downregulation of …
A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis
R Darbousset, L Senkpeil, J Kuehn, S Balu, D Miglani… - bioRxiv, 2025 - biorxiv.org
Systemic sclerosis (SSc) is characterized by progressive fibrosis of skin, lung, and other
organs and retains among the highest rates of mortality among autoimmune diseases. We …
organs and retains among the highest rates of mortality among autoimmune diseases. We …
Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization
Background: Despite antiplatelet therapy, some patients remain at high risk for ischemic
events due to medication non-responsiveness or High Residual Platelet Reactivity (HRPR) …
events due to medication non-responsiveness or High Residual Platelet Reactivity (HRPR) …
[PDF][PDF] Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
ID Pokrovskaya, KK Ball, MW Webb, SW Rhee, J Ware… - 2025 - preprints.org
Platelet glycoprotein (GP) VI is a transmembrane protein that was originally characterized as
a collagen receptor supporting platelet adhesion and activation through its association with …
a collagen receptor supporting platelet adhesion and activation through its association with …