The interplay between Helicobacter pylori and gastrointestinal microbiota

CC Chen, JM Liou, YC Lee, TC Hong, EM El-Omar… - Gut …, 2021 - Taylor & Francis
The complex population of microbes in the human gastrointestinal (GI) tract interacts with
itself and with the host, exerting a deep influence on health and disease development. The …

Intratumoural microbiota: from theory to clinical application

H Ji, Z Jiang, C Wei, Y Ma, J Zhao, F Wang… - Cell Communication and …, 2023 - Springer
Cancer is a major cause of high morbidity and mortality worldwide. Several environmental,
genetic and lifestyle factors are associated with the development of cancer in humans and …

Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer

K Lehr, D Nikitina, R Vilchez-Vargas… - Scientific Reports, 2023 - nature.com
Helicobacter pylori (H. pylori) infection has been considered as the main causal factor in
gastric carcinogenesis, but other bacterial species may also play an important role in …

Robustness of cancer microbiome signals over a broad range of methodological variation

GD Sepich-Poore, D McDonald, E Kopylova… - Oncogene, 2024 - nature.com
In 2020, we identified cancer-specific microbial signals in The Cancer Genome Atlas
(TCGA). Multiple peer-reviewed papers independently verified or extended our findings …

Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients

C Neuzillet, M Marchais, S Vacher, M Hilmi… - Scientific Reports, 2021 - nature.com
Abstract Changes in the oral microbiome, particularly Fusobacterium nucleatum, are
associated with oral squamous cell carcinoma (OSCC). F. nucleatum has been reported to …

[HTML][HTML] The intratumor microbiome predicts prognosis across gender and subtypes in papillary thyroid carcinoma

A Gnanasekar, G Castaneda, A Iyangar… - Computational and …, 2021 - Elsevier
While the intratumor microbiome has become increasingly implicated in cancer
development, the microbial landscape of papillary thyroid carcinoma (PTC) is essentially …

The intratumor microbiota signatures associate with subtype, tumor stage, and survival status of esophageal carcinoma

Y Wang, H Guo, X Gao, J Wang - Frontiers in Oncology, 2021 - frontiersin.org
Altered human microbiome characteristic has been linked with esophageal carcinoma
(ESCA), analysis of microbial profiling directly derived from ESCA tumor tissue is beneficial …

[HTML][HTML] Distinct intratumoral microbiome of young-onset and average-onset colorectal cancer

SV Barot, N Sangwan, KG Nair, SL Schmit, S **ang… - …, 2024 - thelancet.com
Background The unexplained rise of young-onset CRC (yoCRC, age< 50 years) is of
concern. Evidence suggests that microbial dysbiosis may be a contributing factor, but the …

From mucosal infection to successful cancer immunotherapy

AG Goubet, M Rouanne, L Derosa, G Kroemer… - Nature Reviews …, 2023 - nature.com
The clinical management of advanced malignancies of the upper and lower urinary tract has
been revolutionized with the advent of immune checkpoint blockers (ICBs). ICBs reinstate or …

Global analysis of microbiota signatures in four major types of gastrointestinal cancer

J Wang, Y Wang, Z Li, X Gao, D Huang - Frontiers in Oncology, 2021 - frontiersin.org
The gut microbiota has been previously linked with tumorigenesis and gastrointestinal
cancer progression; however, intra-tumor microbiota analysis has just emerged and …